The 2nd Annual Big Data Health Science Case Competition will be held virtually between January 29– 31, 2021 before the University of South Carolina’s National Big Data Health Science Conference, scheduled for February 5– 6, 2021. Last year’s winner was Duke University, so it is time for others to compete to dethrone them. The Big Data Case Competition is intended to provide enthusiastic teams of graduate and senior undergraduate students with the opportunity to apply their knowledge to the analysis of big datasets in healthcare.