The National Big Data Health Science Conference is a signature annual event of the USC Big Data Health Science Center (BDHSC). The theme of the 2025 conference is “Unlocking the Power of Big Data in Health: Transforming Data into Actionable Intelligence.” Highlights of the 6th national conference will include keynote and panel speakers from diverse areas of the health sciences, government, and academia, as well as poster sessions, networking events, and breakout sessions in areas of artificial intelligence for sensing and diagnosis, electronic health records, genomics, geospatial, and social media research. Funding for this conference was made possible (in part) by R13LM014347 from the National Library of Medicine.